ea0037oc4.4 | Diabetes | ECE2015
Sun Zilin
, Li Fengfei
, Chen Bijun
, Li Ling
, Zha Min
, Xu Wei
, Zhou Shaoxia
, Bachem M G
Background: Evidence suggests that pancreatic stellate cells (PSCs) are present in intra-/peri-islets in type 2 diabetes mellitus (T2DM). We isolated stellate cell from islets (ISC) of Goto-Kakizaki (GK) rats. Given these cells are intra-islets, which possibly affect the biological behavior of β-cell. This study was designed to determine the effects of ISC isolated from fibrotic islets of GK rats on β-cell function and survival.Methods: ISC was...